Cure First

At Cure-First we've spent years developing the PARIS Test. Functional precision medicine has begun transforming oncology by shifting our focus from what tumor genes might do to how patient cells actually respond to therapy in real time. Check out the link below to see the moment where ASCO realizes this technology can't be overlooked any longer!

https://connection.asco.org/do/asco-clinical-notice-asco-clarification-status-functional-precision-medicine-fpm

ASCO Clinical Notice: ASCO Clarification on the Status of Functional Precision Medicine (FPM) ASCO officially clarifies its support for the advancement of functional precision medicine (FPM) to improve clinical outcomes for patients with cancer. ASCO explicitly states that its historical guidelines regarding early-generation assays do not reflect active organizational policy and must not ser...

This month we launched Fight Like Layla, a campaign to create a Pediatric Access Fund so that children with cancer can receive the PARIS® functional precision medicine test.
The campaign is inspired by an unexpected and heartbreaking reality. In recent months, families across the country have reached out to Cure First because their children are battling one of the most devastating pediatric brain tumors: ependymoma.
For these children, surgery is often the only treatment capable of keeping the cancer under control. But a child's brain can only endure so many operations before there are no more options.
Through the PARIS test, we have already identified promising drug candidates for several children. But one little girl's tumor was different. In our standard panel of nearly 50 drugs, only one drug showed activity.
Our team refused to stop looking.
We tested our entire research library of more than 200 drugs. The expanded screen identified three additional drugs targeting the same vulnerable pathway, as well as two targeted drugs—primarily used for thyroid cancer—that act through a second pathway. The test also confirmed sensitivity to the one drug that had previously helped this little girl, giving her physician greater confidence that it could work again.
This was a child believed to have exhausted every option.
These results give us tremendous hope that functional precision medicine can open new treatment possibilities for children facing devastating cancers. Tragically, many families simply cannot afford the testing.
That is why we created Fight Like Layla. Please note, 100% of donations to the Fight Like Layla Pediatric Access Fund go directly toward providing PARIS testing for children with cancer.

With deep appreciation to generous funders, every donation—up to a total of $100,000—will be matched this month. Every dollar you give will be doubled!

GoFundMe Link: https://www.gofundme.com/f/how-do-you-know-a-cancer-treatment-will-work

For inquiries about the PARIS test:
E-mail: [email protected]
or call: (425) 366-7614

Donate to How Do You Know a Cancer Treatment Will Work?, organized by Carla Grandori Empowering Cancer Patients With Data-Driven Treatment Decisions When … Carla Grandori needs your support for How Do You Know a Cancer Treatment Will Work?

Our Kids Fundraising campaign “ Fight like Layla” is up on Times Square🤩Thanks to the family of a patient that was helped by the PARIS test. Please share and donate, this fund will allow access to the PARIS test to the several children right now, who needs to find the best drugs for their fight with brain tumors.

https://gofund.me/3aa0c3087

BIG NEWS!! $100K Donor Match for THE KIDS in June! Help us raise $200K to help kids get Cure FIrst's PARIS test!

Cure First is collaborating with Cancer Revengers, the maverick's of pediatric brain cancers who are changing everything. Several generous donors have come together to match up to $100K in June, a total of up to $200K if we max it out! The cancer kids are the little soldiers often left behind and we're teaming up with Cancer Revengers to begin to fix that. Please donate today and honor the late Cancer Revenger co-founder and original superhero, Layla, who absolutely changed the game in functional precision medicine for kids. We are thrilled to be a part of this movement for kids and thank you for all of your support. Let's hit $200K in June so please share this and send to friends!

Donate at cure-first.org/kids

Following an inspiring week at AACR 2026, Cure First is doubling down on our mission to redefine precision oncology. We are currently refining our functional drug screening data to provide oncologists with a clearer, more actionable roadmap for selecting the next line of treatment—ensuring every patient gets the right therapy at the right time.