ENDIA

Congratulations to our ENDIA Graduate of the Week — Ashton! 🎉

Ashton has completed his ENDIA journey and we couldn't be prouder.
A huge thank you to Ashton's mum too, whose support and dedication made it all possible.
Behind every ENDIA graduate is a family who showed up, time and time again — and that means the world to us. 💙
Thank you, Ashton and family.
You've played a real part in helping us understand type 1 diabetes.

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There have been associations found between the development of and another condition, .

Certain inherited gene variants in a region called HLA (human leukocyte antigen - controls how the immune system recognises threats) are the strongest known genetic risk factors for type 1 diabetes ( ) and coeliac disease ( ). One particular genetic profile — called HLA-DR3 — increases the chance of developing both.

Scientists using TEDDY Study data found, within people already carrying the HLA-DR3 profile, a specific set of three small genetic variations called a "tri-SNP". The tri-SNP acts like a switch — but the switch works in opposite directions for the two conditions.

This "switch" that protects against diabetes seems to increase the risk for coeliac disease, and vice versa.

The tri-SNP helps explain why some people develop type 1 diabetes, others develop coeliac disease, and some develop both.

Understanding this genetic fine-tuning could help build more precise risk prediction models and may ultimately point toward more personalised approaches to monitoring and prevention.

We found this to be a pretty technical paper, but available to read more online at https://doi.org/10.7554/eLife.89068

If you are a parent or caregiver of a child living with type 1 diabetes (T1D) in Australia, please consider sharing your experiences of childcare/preschool to help inform safe and inclusive care, via the The Australian Centre for Behavioural Research in Diabetes online survey: https://lnkd.in/gr47MB-J

New research study opportunity for parents and guardians of children with T1D who live in Australia!

The ACBRD and The Kids Research Institute Australia want to hear about your preschool/childcare experiences in a short online survey (15-20 minutes). By taking part, you will help improve childcare/preschools to be safer and more inclusive for children living with T1D.

To take part, visit: tinyurl.com/T1D-preschool

Diabetes Victoria | Deakin University

This is the end of study participation for ENDIAN, Emmy.

Emmy was smiley and brave as usual, but perhaps even braver with her big sister, Abby, coming for support and to say goodbye.

Goodbye, Emmy, and thank you for being an ENDIAN. We hope you feel proud of what you have been a part of. Thank you.

There’s a lot to be proud about with the ENDIA Study.

It’s a study of nearly 1300 babies. And here are two of them; babies no more!

These two sisters have grown up as participants in this research since they were born! At their final study visit their proud Mum, and proud Professor, celebrated with gold medals and certificates outlining all they have contributed.

And that contribution is definitely something to be proud of. Well done girls, and .

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Leo! So long.

A big congratulations to Leo on completing his ENDIA journey! 🎉

Almost 10 years old and already a research champion — Leo has been part of the ENDIA Study and his contribution means so much to our understanding of

Thank you to Leo and his mum for showing up for science and helping us to find the causes of . 💙

Excellent Eva has exited ENDIA.

Could that smile be any wider? Could that hug be any squishier? Could that medal be any shinier? Could that girl be any braver?

We think not. Congratulations and thank you, Eva, for your wonderful contributions to type 1 diabetes research with the .

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From the very first visit to the very last day,
Jaxson showed up in a remarkable way.
Samples for science, given with heart —
Big thanks to Jaxson, for playing his part.

This we’d like to acknowledge one of our many ENDIA participants, Ava, for her amazing contributions to the ENDIA Study and type 1 diabetes research.

Ava made sure her very last samples were processed with care by our ENDIA scientists ready for future analysis to advise future advancements in our knowledge and prevention of T1D.

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Well done, William! You’ve finished your research visits with nurse, Helen, and the .

The final visit was marked with a graduation ceremony cheered on by his brother and sister who were very proud of him.

Nurse Helen will miss you very much. Thank you for everything, young man.

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