GenDx

Why do some patients respond to immune checkpoint inhibitors and others don't?

In our latest post, we explore how a patient's HLA type may be associated with the response to immune checkpoint inhibitors.

It's the third post in our CDx blog post series on "Exploring HLA in tumors", where we previously introduced the central role of HLA molecules in tumor immunology and discussed how tumors can alter HLA pathways to evade immune detection and destruction.

🔗 Read it here:
https://www.gendx.com/2026/07/exploring-hla-in-tumors-the-role-of-hla-in-immune-checkpoint-inhibitor-therapy/

Exploring HLA in tumors: The role of HLA in immune checkpoint inhibitor therapy In this blog post, we explore how a patient's HLA type may associate with the efficacy of immune checkpoint inhibitors.

1,000 patients pre-screened for HLA-A for the ARTEMIA trial🥳

In collaboration with OSE Immunotherapeutics, the sponsor of the ARTEMIA trial, GenDx has reached a significant milestone: 1,000 patients have now been pre-screened using a test for high-resolution HLA-A*02 typing, which is currently under companion diagnostic development. One step closer to Non-Small Cell Lung Cancer (NSCLC) patients getting new options for treatment.

Developed and validated since 2023, our assay is based on our IVDR-registered devices, NGSgo®-AmpX v2, NGSgo® Library Full Kit, and NGSengine® software. The assay is validated through an IVDR clinical performance study. It supports the pivotal phase 3 ARTEMIA clinical trial of Tedopi®, an HLA-restricted epitope-based cancer vaccine, for second-line treatment of NSCLC patients with secondary resistance to Immune Checkpoint Inhibitors (ICI).

➡️ Clinicaltrials.gov: NCT06472245

🔗 Learn more about our CDx services:
https://www.gendx.com/companion-diagnostics/introduction/

🔗 Learn more about Tedopi® and the ARTEMIA trial in our webinar:
https://www.gendx.com/education/on-demand-webinars/

When time is critical, your HLA amplification step should be fast, precise, and simple.
That is exactly what our team had in mind when developing NGSgo®-ProntoAmp.

By combining pre-mixed primers and enzymes, we've simplified the setup; all you need to do is add DNA.

Compatible with both Illumina (via NGSgo® Library Full Kit) and Oxford Nanopore Technologies (via NGS-Pronto®Prep) sequencing platforms.

Learn more about this product on our website:
🔗 https://www.gendx.com/product_line/ngsgo-prontoamp/

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How reliable is NGSgo®-ProntoAmp? The results in 3 external clinical labs speak for themselves.

In a recent study, NGSgo®-ProntoAmp delivered high-quality HLA typing results from both blood and buccal swab samples, validated on Illumina and Oxford Nanopore Technologies platforms.

The numbers:
🔹 80 human gDNA samples typed
🔹 99.7% - 100% concordance

Swipe through to see the full picture 👇

🔗 Explore the complete Application Note:
https://www.gendx.com/2026/04/application-note-robust-hla-typing-with-ngsgo-prontoamp/

CareDx Lab Products portfolio is now officially becoming part of GenDx!

By integrating these highly complementary product portfolios, we are creating one of the most comprehensive offerings in molecular transplant diagnostics.

Together, our portfolio now includes:
➡️ HLA typing solutions based on NGS and real-time PCR
➡️ High-resolution HLA sequencing assays
➡️ Analysis software and workflow solutions
➡️ Products supporting transplantation monitoring
➡️ Education, training, and scientific support

There will be no disruption to products, services, customer support, or ongoing activities for existing GenDx and CareDx Lab Products customers.

Over the coming period, CareDx Lab Products will be fully integrated into the GenDx brand, while maintaining the quality, expertise, and customer focus you know and trust.

Together, we look forward to continuing to support laboratories with comprehensive solutions that help improve the quality of life and survival of transplant patients.

Welcome to this new chapter!

When does the immune system, meant to protect us, start helping tumors hide?

HLA molecules are far more than transplant biomarkers. Tumors can hijack HLA biology to evade immune surveillance and create an immunosuppressive microenvironment.

Our latest blog explores how classical and non-classical HLA pathways contribute to immune escape and why these same pathways are emerging as promising therapeutic targets.

Read our new CDx blog post👇

Exploring HLA in tumors: Immune evasion through HLA modulation in cancer As introduced in the previous blog post in this series, HLA molecules are central to the presentation of tumor antigens […]

Delivering fast, high-quality results is critical for labs.

We partnered with Illumina to validate our NGSgo® solutions on the MiSeq™ i100 System, enabling laboratories to transition seamlessly while maintaining the performance they rely on.

In this video, Kavita Shah, Illumina, Inc. Sr. Staff Product Manager NGS Benchtop Systems, together with Daan 't Hart, GenDx Sr. Sales and Application Specialist, share more about our partnership and the benefits it brings to laboratories using our NGSgo® solutions.

NGSgo® Just Got Faster: We Validated It on the MiSeq™ i100 System Delivering fast, high-quality results is critical for labs. We pa...

Participants from 24 countries. 15 different sports. Athletes ranging in age from 8 to 80 years old.

They all come together to celebrate what it means to have received the "Gift of Life." The European Transplant Games 2026 event highlights the importance of transplantation and sport as a way of life.

Hosted in Arnhem, the Netherlands, from June 21 to 27, it brings together athletes, organ and stem cell transplant recipients, and people undergoing dialysis, together with their families.

Every athlete competing in games is a reminder of why precision in transplantation matters. We are honored to support this year's European Transplant Games.

Become a part of the event too!
Visit the European Transplant Games 2026 website for more information:
▶️ https://etg2026.nl/

European Transplant Games 2026 - Arnhem, The Netherlands There is life after transplantation. This is what the European Transplant Games showcase. This multi-sport event will take place in Arnhem from June 21 to June 27 2026.

At GenDx, we are committed to contributing to a more sustainable future, both within healthcare and across our operations.

Today, we are proud to share our first public Sustainability Report📄 , which relates to 2025.

The report gives an overview of the sustainability initiatives and practices currently in place across GenDx, covering areas such as environmental impact, employee wellbeing, waste reduction, operational efficiency, and governance.

To the report ⬇️
https://www.gendx.com/2026/06/sustainability-report-2025/

We look forward to welcoming you to our upcoming webinar:
"Introducing NGSgo-ProntoFLX: Flexible High-Resolution HLA Typing on Oxford Nanopore Sequencing Platforms"

📅 June 24
🕛 12:00 CEST︱19:00 CEST
📍 Online
🔗 https://www.gendx.com/gendx_education/webinar-introducing-ngsgo-prontoflx-flexible-high-resolution-hla-typing-on-oxford-nanopore-sequencing-platforms/

Recently, we launched NGSgo-ProntoFLX for HLA-A, HLA-B, and HLA-DQA1/-DQB1, our new solution for targeted high-resolution HLA typing using Oxford Nanopore Technologies sequencing.

In this webinar, Eline ter Steege, PhD, Project Manager R&D at GenDx, will introduce NGSgo-ProntoFLX and discuss the technology and workflow behind the product. She will also provide an update on the ongoing development of assays for the remaining HLA loci. The webinar host is Bo Rood, Technician R&D at GenDx.

For more information, visit our website (link in the comments section). 👇