Advanced Medical Therapeutics

In a mouse study, aging blood stem cells in bone marrow appeared to contribute to inflammation and signs of decline in distant organs. Boosting a protein called SIRT3 in transplanted stem cells improved measures of muscle function, blood sugar control, memory, and lung health. This is preclinical research and does not show that SIRT3 slows human aging, but it adds evidence that blood and immune cells may influence whole-body aging. https://bit.ly/4qwCBHk

One Overlooked Part of Your Body May Be Driving Aging Everywhere Else Bones do more than hold your body upright.

Can fructose make ovarian cancer spread? A new preclinical study found that ovarian cancer cells surviving chemotherapy released fructose that promoted metastatic behavior, and a high-fructose diet increased cancer spread in animal models. These findings have not been confirmed in people and should not be used to change cancer treatment or make restrictive diet decisions. For now, this is a research lead, not a patient-care recommendation. https://bit.ly/4xkr7tb

Fructose and ovarian cancer metastasis: Is there a link? New preclinical research has made a key discovery regarding the spread of ovarian cancer after chemotherapy. Fructose may play a role, it found.

World Alzheimer's Day is a reminder that changes in memory and thinking deserve attention, not dismissal. This global observance highlights the value of recognizing cognitive changes early, which can help people seek evaluation, understand what may be happening, access support, and plan ahead. If you notice persistent changes in yourself or someone close to you, consider starting the conversation with a healthcare professional.

Taking the stairs may be a small choice with meaningful heart-health associations. A review of 9 studies involving more than 480,000 people found frequent stair climbing was associated with a 39% lower risk of cardiovascular death and a 24% lower risk of death from any cause. This does not prove stairs caused the lower risk, but it supports adding safe bursts of movement throughout your day. https://bit.ly/3UgdtIS

Heart disease: Climbing just 6 flights of stairs a day can lower risk A large review involving almost half a million participants shows why climbing just 6 flights of stairs a day could significantly boost heart health, while reducing risk of death from heart disease and other causes.

Can tomatoes help support liver health? In a small 6-week randomized trial of 79 adults with metabolic dysfunction-associated liver disease, daily raw tomatoes plus tomato sauce led to a greater decrease in liver fat than a tomato-free diet. Other liver and metabolic markers did not significantly improve. Tomatoes can be part of a healthy eating pattern, but this early study does not establish them as a treatment for fatty liver disease. https://bit.ly/3UA7WNk

MASLD: Eating tomatoes daily may help lower liver fat buildup People with MASLD who ate tomatoes on a daily basis had less fat buildup in the liver, a recent study found.

Blood pressure control may depend on more than cutting salt. A new report highlights evidence that lowering sodium while increasing potassium through food can support better blood pressure control. Potatoes, beans, spinach, yogurt, salmon, and fruit can all contribute potassium. If you have kidney disease, heart failure, high potassium levels, or take medications that affect potassium, check with your healthcare professional before increasing your intake. https://bit.ly/3UjvwxO

Hypertension: Why boosting potassium may be key for control Current hypertension guidelines could be overlooking something important: increasing potassium intake while lowering sodium intake may be more effective at reducing blood pressure. Three experts weigh in with their thoughts.

Estrogen-only hormone therapy and Alzheimer's disease are being studied closely. In an observational analysis, women who had used estrogen-only therapy showed 35% lower odds of hallmark Alzheimer's brain changes on autopsy, along with several better dementia-related outcomes. The study cannot prove estrogen prevents Alzheimer's, and estrogen-only therapy is not appropriate for everyone. Hormone decisions should be individualized with a healthcare professional. https://bit.ly/3Uiwevd

Dementia: Study links estrogen-only menopausal therapy to lower risk A study found that people who used estrogen-only menopausal hormonal therapy were less likely to show increased Alzheimer’s disease pathology, and lower chances of memory decline and a dementia diagnosis.

Does healthy aging mean eating less protein? Not necessarily. A review of more than 350 papers suggests that restricting certain amino acids may influence metabolic and cellular aging pathways, but much of the longevity evidence comes from animal research. Protein needs vary by age, activity level, and health. Adults over 65 may be especially vulnerable to low protein intake, so avoid cutting protein based on headlines alone. https://bit.ly/4xYHBHl

Longevity and protein: Restricting 3 amino acids may help extend life A new study outlines how cutting 3 specific protein building blocks from your diet by reducing protein could help you live longer and promote healthy aging and improve metabolism.

Happy Labor Day! Today is a chance to recognize the work and contributions that keep our communities moving. If you have time off, use part of the day to recharge in a way that feels good, whether that means resting, getting outside, sharing a meal, or simply stepping away from your usual routine. Wishing you a safe and restorative holiday.

Worried that statins automatically cause weight gain? Current evidence does not show weight gain as a direct, established side effect of statins. Some people gain weight while taking them, often alongside changes in diet or activity, and researchers are still studying possible metabolic effects. Keep focusing on balanced nutrition and regular movement, and talk with your clinician before making any medication changes. https://bit.ly/4qFbxG8

Do statins cause weight gain: Causes, research, and what to do Learn more about the link between statins and weight gain, including possible causes, what to do about it, and statin alternatives.