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💭 In your opinion, how many clinical trials that claim to be "pragmatic" are successful in providing useful evidence for real-world decision-making?

JAMA+ Trials wants to hear from you. Share your perspective in our latest poll and help spark discussion around the future of clinical trial research.

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📢 Share your opinion: New JAMA+ Trials Poll!

How many clinical trials that claim to be "pragmatic" actually provide useful evidence for real-world decision-making?

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📣 Tomorrow, JAMA and JAMA Network Editor in Chief Kirsten Bibbins-Domingo, MD, PhD, MAS will join leaders from public health, academia, and city resilience at Yale University Climate Week NYC for Resilient Cities, Reimagining Health.

📅 September 22, 2026
🕘 9:00-10:30 a.m. ET

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📈 Among individuals eligible for who currently smoked, all smoking cessation intervention classes evaluated were cost-saving compared with screening alone over a lifetime horizon. These findings indicate that integrating pharmacotherapy and counseling into screening programs may be a highly efficient use of health care resources and may help health systems choose cessation strategies based on available budget and implementation capacity.

https://ja.ma/4rb5nO1

📈 Among infants younger than 12 months who were tested for respiratory syncytial virus ( ) in 2 Canadian provinces, receipt of was associated with lower risk of RSV-related emergency department visits, hospitalization, and intensive care unit admission. Estimated effectiveness remained high across subgroups, supporting the potential of nirsevimab to reduce severe RSV disease requiring hospital-based care.

https://ja.ma/4xtohkK

📊 In a nationwide survey of health center patients, food insecurity was associated with a higher likelihood of referral to food assistance, but referral rates remained low overall. More than one-third of patients with food insecurity reported receiving neither SNAP or WIC nor a health center referral, indicating gaps in connection to food support services.

https://ja.ma/4hqm3xE

📊 Among older inpatients with at admission, ward-based implementation of a nutrition clinical framework was associated with lower in-hospital mortality and shorter length of stay. No similar associations were observed in the overall, suggesting targeted clinical nutrition delivery may be a useful strategy for
prioritizing limited dietitian resources for high-risk inpatients.

https://ja.ma/4yXiTYv

🧠 Among people with undergoing repeated MRI over up to 10 years, gray matter volume trajectories were associated with cumulative illness burden rather than diagnosis alone or acute symptom fluctuations. Greater cumulative illness severity was associated with steeper decline in the hippocampus and dorsolateral prefrontal cortex, supporting individualized, time-sensitive neurobiological models of depression.

https://ja.ma/4yD8rVK